Wednesday, September 24, 2014

Rheumatoid Arthritis and Sex Hormones

Rheumatoid Arthritis and Sex Hormones
A review of the current medical literature shows that sex hormones can actually
block some important mechanisms involved in the development of Rheumatoid
arthritis, including immunoregulation, inflammatory response, cytokine reactions,
and cartilage damage.

In premenopausal women, most studies indicate a strong correlation between
low androgen levels (DHEA, testosterone) and the progression of RA. In a study
of 49 postmenopausal women with rheumatoid arthritis, DHEA levels were
significantly lower than in healthy controls. [Gaby, AR. Holistic Medicine. Spring,
1993: p.22]

Numerous studies have shown that men with RA often present with low
testosterone levels. Several studies have suggested that testosterone may play a
protective role in RA, with initial deficiencies setting the stage for development of
the disease.

If you are concerned or have a family history of Rheumatoid arthritis, get your levels tested. Dr. Lund has taken post graduate classes on this subject. Call her office for an appointment. 209-536-9182

1. Da Silva JA, Hall GM. The effects of gender and sex hormones on
outcome in rheumatoid arthritis. Baillieres Clin Rheumatol 1992; 6(1):196-
2. Masi AT. Sex hormones and rheumatoid arthritis: cause or effect
relationships in a complex pathophysiology? Clin Exp Rheumatol
3. Cutolo M, Balleari E, Giusti M, Monachesi M, Accardo S. Sex hormone
status in women suffering from rheumatoid arthritis. J Rheumatol
4. Benito US, Arnalich FF, Gonzalez-Gancedo P, de Miguel Mendieta E,
Gijon BJ. The hormonal changes in postmenopausal women with
rheumatoid arthritis [In Spanish]. Rev Clin Esp 1992;190(40):181-3.
5. Cutolo M, Balleari E, Giusti M, Monachesi M, Accardo S. Sex hormone
status of male patients with rheumatoid arthritis: evidence of low serum
concentrations of testosterone at baseline and after human chroionic
gonadotropin stimulation. Arthritis Rheum 1988;31(10):1314-1317.
6. Martens HF, Sheets PK, Tenover JS, Dugowson CE, Bremner WJ,
Starkebaum G. Decreased testosterone levels in men with rheumatoid
arthritis: effect of low dose prednisone therapy. J Rheum 1994;21(8):1427-
7. Spector TD, Perry LA, Tubb G, Silman AJ, Huskisson EC. Low free
testosterone levels in rheumatoid arthritis. Ann Rheum Dis 1988 47(1):65-
8. Spector TD, Ollier W, Perry LA, Silman AJ, Thompson PW, Edwards A.

Free and serum testosterone levels in 276 males: a comparative study of